This just in…as posted on About.com
Alvine Pharmaceuticals today said it’s gotten “clinical proof of principle” in its latest trial of ALV003, a drug compound the company hopes eventually will become the first approved pharmaceutical treatment for celiac disease.
In the Phase 2a trial, 41 biopsy-proven celiac disease patients who had been following the gluten-free diet for at least one year received either ALV003 or a placebo daily for six weeks. They also ate two grams of gluten each day of bread crumbs (about one bite of bread).
The study participants underwent a biopsy at the beginning for the trial and following the six-week gluten challenge to see how their intestinal linings fared.
Biopsy results from 34 of the 41 patients showed there was significantly less intestinal damage in patients treated with ALV003 than in placebo-treated patients at the six-week mark. In addition, patients receiving the placebo had more “adverse events,” defined as abdominal distension, flatulence, belching, abdominal pain and diarrhea.
Here’s my question. Even if there was a drug…would you go back to eating gluten?
At this point, as much as a pain in the butt it is to be gluten free, I can’t imagine crossing that line and ingesting gluten again. There’s more to gluten for us celiacs than just the intestines. Speaking from experience, it affects my entire being, and I have no desire to go to that dark place if I don’t have to.
I have celiac. To me, that’s life’s way of saying…”Hey, you shouldn’t be eating that stuff. It’s really, really bad for you.” No drug will change that.